ADAM33 基因S2 位点多态性与新疆维吾尔族人群哮喘的相关性研究_《中国呼吸与危重监护杂志》

作者：

桑珂 , 胡昕 , 王琼 , 齐曼古力吾守尔

新疆医科大学第一附属医院呼吸一科( 新疆乌鲁木齐830054)通信作者: 齐曼古力· 吾守尔, E-mail: qimenw@ hotmail. com;

关键词：

支气管哮喘解整合素-金属蛋白酶33 基因等位基因单核苷酸多态性

DOI：

DOI: 10 . 7507 /1671 -6205 . 20130106

视频：

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摘要 全文 图表 视频 参考文献 施引文献 补充材料

目的探讨解整合素-金属蛋白酶33 基因S2 位点多态性与新疆维吾尔族人群支气管哮喘的相关性。
方法纳入131 例新疆维吾尔族支气管哮喘患者( 病例组) 与90 例新疆维吾尔族健康体检者( 对照组) , 应用聚合酶链和限制片段长度多态性( PCR-RFLP) 方法分析ADAM33 基因S2 位点单核苷酸多态性。
结果 ADAM33 基因S2 位点3 种基因型比较差异有统计学意义( X2 = 6. 065,P lt;0. 05) ; 2 组等位基因频率比较差异有统计学意义(X2 =5. 255, P lt; 0. 025) ; S2 位点G 等位基因有增加患哮喘的风险( OR= 1. 616, P lt;0. 05) ; S2 位点的CG 基因型有增加患哮喘的风险( OR= 1. 351,P lt;0. 05) , 哮喘组ADAM33 基因S2 位点3 种基因型间FEV1% pred 和FVC% pred 比较差异有统计学意义( F =6. 248, P lt;0. 01; F = 7. 067, P lt; 0. 01) 。
结论 ADAM33 基因S2 位点与新疆维吾尔族支气管哮喘具有明显相关性, 并且增加维吾尔族人群患哮喘的风险。

引用本文： 桑珂,胡昕,王琼,齐曼古力吾守尔. ADAM33 基因S2 位点多态性与新疆维吾尔族人群哮喘的相关性研究. 中国呼吸与危重监护杂志, 2013, 12(5): 442-445. doi: DOI: 10 . 7507 /1671 -6205 . 20130106 复制

1.	Primakoff P, Myles DG. The ADAM gene family: surface proteins with adhesion and protease activity. Trends Crenet, 2000, 16: 83 -87 .
2.	Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.Nature, 2002, 418 : 426-430.
3.	中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南. 中华结核和呼吸杂志, 2008, 31 : 177-185.
4.	Yoshinaka T, Nishii K, Yamada K, et al. Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity. Gene, 2002, 282( 1 /2) : 227-236.
5.	Dijkstra A, Vonk JM, Jongepier H, et al. Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex.Thorax, 2006 , 61: 105-110.
6.	Hirota T, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy, 2006, 36: 884 -891.
7.	迟翔宇, 王学群, 王来城, 等. 支气管哮喘患者ADAM33 基因S2位点多态性的研究. 临床内科杂志, 2011, 28 : 47-49.
8.	Awasthi S, Tripathi P, Husain N, et al. Association of ADAM33 gene polymorphisms with asthma in Indian children. JHum Genet,2011, 56: 188-195 .
9.	de Faria IC, de Faria EJ, Toro AA, et al. Association of TGFbeta1,CDl4, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents. J Pediatr ( Rio J) ,.
10.	Matsusue A, Kiyohara C, Tanaka K, et al. ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children. Clin Biochem, 2009, 42: 477-483.
11.	Lind DL, Choudhry S, Ung N, et al. ADAM 33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med, 2003 , 168: 1312-1316.
12.	Lee JH, Park HS, Park SW, et al. ADAM33 polymorphism:association with bronchial hyper-responsiveness in Korean asthmatics. Clin Exp Allergy, 2004, 34: 860-865 .
13.	Kedda MA, Duffy DL, Bradley B, et al. ADAM33 haplotypes are associated with asthma in a large Australian population. Eur J Hum Genet, 2006 , 14 : 1027-1036.
14.	Hirota T, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy, 2006, 36: 884 -891.
15.	Foley SC, Mogas AK, Olivenstein R, et al. Increased expression of ADAM33 and ADAM8 with disease progression in asthma. J Allergy Clin Immunol, 2007 , 119: 863-871.
16.	Sakagami T, Jinnai N, Nakajima T, et al. ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population. J Hum Genet, 2007, 52: 66-72 .
17.	Tripathi P, Awasthi S, Prasad R, et al. Association of ADAM33 gene polymorphisms with adult-onset asthma and its severity in an Indian adult population. J Genet, 2011, 90: 265-273.
18.	Fang Q, Zhao H, Wang A, et al. Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han Population. BMC Med Genet, 2011, 12: 133.
19.	, 84: 203-210 .

1. Primakoff P, Myles DG. The ADAM gene family: surface proteins with adhesion and protease activity. Trends Crenet, 2000, 16: 83 -87 .
2. Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.Nature, 2002, 418 : 426-430.
3. 中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南. 中华结核和呼吸杂志, 2008, 31 : 177-185.
4. Yoshinaka T, Nishii K, Yamada K, et al. Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity. Gene, 2002, 282( 1 /2) : 227-236.
5. Dijkstra A, Vonk JM, Jongepier H, et al. Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex.Thorax, 2006 , 61: 105-110.
6. Hirota T, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy, 2006, 36: 884 -891.
7. 迟翔宇, 王学群, 王来城, 等. 支气管哮喘患者ADAM33 基因S2位点多态性的研究. 临床内科杂志, 2011, 28 : 47-49.
8. Awasthi S, Tripathi P, Husain N, et al. Association of ADAM33 gene polymorphisms with asthma in Indian children. JHum Genet,2011, 56: 188-195 .
9. de Faria IC, de Faria EJ, Toro AA, et al. Association of TGFbeta1,CDl4, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents. J Pediatr ( Rio J) ,.
10. Matsusue A, Kiyohara C, Tanaka K, et al. ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children. Clin Biochem, 2009, 42: 477-483.
11. Lind DL, Choudhry S, Ung N, et al. ADAM 33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med, 2003 , 168: 1312-1316.
12. Lee JH, Park HS, Park SW, et al. ADAM33 polymorphism:association with bronchial hyper-responsiveness in Korean asthmatics. Clin Exp Allergy, 2004, 34: 860-865 .
13. Kedda MA, Duffy DL, Bradley B, et al. ADAM33 haplotypes are associated with asthma in a large Australian population. Eur J Hum Genet, 2006 , 14 : 1027-1036.
14. Hirota T, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy, 2006, 36: 884 -891.
15. Foley SC, Mogas AK, Olivenstein R, et al. Increased expression of ADAM33 and ADAM8 with disease progression in asthma. J Allergy Clin Immunol, 2007 , 119: 863-871.
16. Sakagami T, Jinnai N, Nakajima T, et al. ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population. J Hum Genet, 2007, 52: 66-72 .
17. Tripathi P, Awasthi S, Prasad R, et al. Association of ADAM33 gene polymorphisms with adult-onset asthma and its severity in an Indian adult population. J Genet, 2011, 90: 265-273.
18. Fang Q, Zhao H, Wang A, et al. Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han Population. BMC Med Genet, 2011, 12: 133.
19. , 84: 203-210 .

《中国呼吸与危重监护杂志》

ADAM33 基因S2 位点多态性与新疆维吾尔族人群哮喘的相关性研究

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《中国呼吸与危重监护杂志》

ADAM33 基因S2 位点多态性与新疆维吾尔族人群哮喘的相关性研究

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